diff --git a/phosphor-regulators/src/chassis.cpp b/phosphor-regulators/src/chassis.cpp
index 85e8275..f84540d 100644
--- a/phosphor-regulators/src/chassis.cpp
+++ b/phosphor-regulators/src/chassis.cpp
@@ -30,6 +30,15 @@
     }
 }
 
+void Chassis::clearCache()
+{
+    // Clear any cached data in each device
+    for (std::unique_ptr<Device>& device : devices)
+    {
+        device->clearCache();
+    }
+}
+
 void Chassis::closeDevices(Services& services)
 {
     // Log debug message in journal
diff --git a/phosphor-regulators/src/chassis.hpp b/phosphor-regulators/src/chassis.hpp
index 86d99f8..7462094 100644
--- a/phosphor-regulators/src/chassis.hpp
+++ b/phosphor-regulators/src/chassis.hpp
@@ -86,6 +86,11 @@
     void addToIDMap(IDMap& idMap);
 
     /**
+     * Clear any cached data about hardware devices.
+     */
+    void clearCache();
+
+    /**
      * Close the devices within this chassis, if any.
      *
      * @param services system services like error logging and the journal
diff --git a/phosphor-regulators/src/device.cpp b/phosphor-regulators/src/device.cpp
index 062ff27..1290077 100644
--- a/phosphor-regulators/src/device.cpp
+++ b/phosphor-regulators/src/device.cpp
@@ -37,6 +37,16 @@
     }
 }
 
+void Device::clearCache()
+{
+    // If presence detection is defined for this device
+    if (presenceDetection)
+    {
+        // Clear cached presence data
+        presenceDetection->clearCache();
+    }
+}
+
 void Device::close(Services& services)
 {
     try
diff --git a/phosphor-regulators/src/device.hpp b/phosphor-regulators/src/device.hpp
index ccdb30a..75ff904 100644
--- a/phosphor-regulators/src/device.hpp
+++ b/phosphor-regulators/src/device.hpp
@@ -87,6 +87,11 @@
     void addToIDMap(IDMap& idMap);
 
     /**
+     * Clear any cached data about hardware devices.
+     */
+    void clearCache();
+
+    /**
      * Closes this device.
      *
      * Closes any interfaces that are open to this device.  Releases any other
diff --git a/phosphor-regulators/src/manager.cpp b/phosphor-regulators/src/manager.cpp
index 51c8944..73e49bf 100644
--- a/phosphor-regulators/src/manager.cpp
+++ b/phosphor-regulators/src/manager.cpp
@@ -90,6 +90,9 @@
 
 void Manager::configure()
 {
+    // Clear any cached data or error history related to hardware devices
+    clearHardwareData();
+
     // Verify System object exists; this means config file has been loaded
     if (system)
     {
@@ -181,7 +184,7 @@
             // Close the regulator devices in the system.  Monitoring is
             // normally disabled because the system is being powered off.  The
             // devices should be closed in case hardware is removed or replaced
-            // while the system is at standby.
+            // while the system is powered off.
             system->closeDevices(services);
         }
     }
@@ -200,6 +203,21 @@
     // collect/update telemetry for each regulator
 }
 
+void Manager::clearHardwareData()
+{
+    // Clear any cached hardware presence data
+    services.getPresenceService().clearCache();
+
+    // Verify System object exists; this means config file has been loaded
+    if (system)
+    {
+        // Clear any cached hardware data in the System object
+        system->clearCache();
+    }
+
+    // TODO: Clear error history related to hardware devices
+}
+
 void Manager::findCompatibleSystemTypes()
 {
     using namespace phosphor::power::util;
diff --git a/phosphor-regulators/src/manager.hpp b/phosphor-regulators/src/manager.hpp
index 6c77fb7..f1aa0d9 100644
--- a/phosphor-regulators/src/manager.hpp
+++ b/phosphor-regulators/src/manager.hpp
@@ -94,6 +94,15 @@
 
   private:
     /**
+     * Clear any cached data or error history related to hardware devices.
+     *
+     * This method should be called when the system is powering on (booting).
+     * While the system was powered off, hardware could have been added,
+     * removed, or replaced.
+     */
+    void clearHardwareData();
+
+    /**
      * Finds the list of compatible system types using D-Bus methods.
      *
      * This list is used to find the correct JSON configuration file for the
diff --git a/phosphor-regulators/src/system.cpp b/phosphor-regulators/src/system.cpp
index a032935..3cc2eb3 100644
--- a/phosphor-regulators/src/system.cpp
+++ b/phosphor-regulators/src/system.cpp
@@ -34,6 +34,15 @@
     }
 }
 
+void System::clearCache()
+{
+    // Clear any cached data in each chassis
+    for (std::unique_ptr<Chassis>& oneChassis : chassis)
+    {
+        oneChassis->clearCache();
+    }
+}
+
 void System::closeDevices(Services& services)
 {
     // Close devices in each chassis
diff --git a/phosphor-regulators/src/system.hpp b/phosphor-regulators/src/system.hpp
index 2ef14b8..715cb4b 100644
--- a/phosphor-regulators/src/system.hpp
+++ b/phosphor-regulators/src/system.hpp
@@ -61,6 +61,11 @@
     }
 
     /**
+     * Clear any cached data about hardware devices.
+     */
+    void clearCache();
+
+    /**
      * Close the regulator devices in the system.
      *
      * @param services system services like error logging and the journal